RNABioPrecisionSyncing biology for healthOur founders
RNABioPrecision brings together experimental biology and computational RNA engineering to advance the design of regulatory RNAs.
Explore selected publications ↓Co-founder & CEO
Elham Dianati is a cell and molecular biologist with experience in translational cancer research and laboratory leadership. Her work encompasses experimental models of cancer and the study of biological responses in cells and tissues.
She is a Research Officer at the Institute for Research in Immunology and Cancer (IRIC), Université de Montréal. Her experimental background complements RNABioPrecision’s computational approach to regulatory RNA design.
Co-founder & CSO
François Major is a professor in the Department of Computer Science and Operations Research at Université de Montréal and Principal Investigator of the RNA Engineering Research Unit at IRIC.
His research spans RNA three-dimensional structure prediction, microRNA interaction networks, and the design of regulatory RNAs. From early computational modeling to transcriptome-wide interaction maps, this work provides a scientific foundation for RNABioPrecision’s approach to coordinated gene regulation.
Selected scientific work
Ten selected publications by François Major and collaborators, spanning 1991–2026. Together, they connect molecular structure, target recognition, and the design and modeling of regulatory RNAs.
Chasles S, Gaillard-Duchassin Z, Quenneville J, Lemaire M, Gagnon E, Major F. Genome Biology 27, 112 (2026).
Maps structurally modeled human microRNA–target interactions across the transcriptome.
Read publicationDupont MJ, Major F. Journal of Molecular Biology 435, 168181 (2023).
Identifies shared structural features in related RNA sequences without requiring sequence alignment.
Read publicationYan Y et al. Nucleic Acids Research 46, 8181–8196 (2018).
Examines how guide sequence and pairing patterns affect the efficiency and specificity of AGO2-mediated silencing.
Read publicationDallaire P et al. Nucleic Acids Research 44, 9956–9964 (2016).
Connects transient RNA structures with differences in microRNA maturation.
Read publicationWeill N et al. Nucleic Acids Research 43, 6730–6738 (2015).
Models how microRNA and target abundance influence competition and regulatory interactions.
Read publicationDe Guire V et al. Nucleic Acids Research 38, e140 (2010).
Explores the design and experimental evaluation of small artificial RNAs directed at multiple selected genes.
Read publicationParisien M, Almeida Cruz J, Westhof E, Major F. RNA 15, 1875–1885 (2009).
Evaluates RNA models through structural differences and the fidelity of their interaction networks.
Read publicationParisien M, Major F. Nature 452, 51–55 (2008).
Connects RNA sequence to secondary and three-dimensional structure prediction.
Read publicationGendron P, Lemieux S, Major F. Journal of Molecular Biology 308, 919–936 (2001).
Provides computational methods to characterize the interactions and geometry of nucleic acid structures.
Read publicationMajor F et al. Science 253, 1255–1260 (1991).
Combines structural constraints and numerical methods for RNA three-dimensional modeling.
Read publicationThese academic studies inform our scientific approach. Learn how that foundation connects to syncBASS and coordinated gene regulation.
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